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Women living in cities at greater risk for breast cancer

Women who live in urban areas have denser breasts, making them more likely to develop breast cancer, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).

“Women living in cities need to pay more attention to having regular breast screening,” said Nicholas M. Perry, M.B.B.S., F.R.C.S., F.R.C.R., director of The London Breast Institute at The Princess Grace Hospital in London, U.K. “Currently, women who live in urban areas are known to have lower attendance for breast screening programs than women in outlying areas.”

Breast tissue in women may be fatty or glandular or a mixture of both. Women with more glandular breasts show denser tissue on a mammogram and are known to have nearly four times the risk of developing breast cancer than women with fatty breasts. Dr. Perry and colleagues set out to determine if there was a relationship between breast density and area of residence.

The researchers analyzed digital mammograms of 972 women from urban, suburban and rural areas. They discovered that women who lived in London had significantly denser breasts than those living outside the city. The risk of increased density was twice as great in the 45- to 54-year-old group. Age-specific analyses suggested that overall differences by area were more pronounced in women under age 50.

Dr. Perry cautioned that more research is needed to determine the precise reason for this phenomenon, taking into account lifestyle factors, stress, workplace and other possible contributors, but he advised that all women maintain a recommended breast screening regimen, and that women with dense breasts be screened with digital mammography, which is more effective at detecting cancer in dense breast tissue.

“Regular breast screening with mammography saves lives,” Dr. Perry said. “Access to breast screening for women living in cities must be prioritized.”

Co-authors are P.C. Allgood, Ph.D., S.W. Duffy, M.D., S.E. Milner, B.Sc., and K. Mokbel, M.D.

Another study presented at RSNA 2007 looked at the influence of the Western lifestyle on breast composition. Miriam Sklair-Levy, M.D., and colleagues from Hadassah Medical Center in Jerusalem compared breast densities of Israeli women and Ethiopian women who immigrated to Israel. The study found that Ethiopian-born women who have immigrated to Israel had significantly lower breast density than did Israeli-born women. In addition, past Ethiopian immigrants who had begun to adopt a Western lifestyle (decreased number of children, change in diet or increased hormone use) had significantly higher breast density than recent immigrants.

Reference: Marv

Hazardous Chemicals in Cosmetics

Many cosmetics contain chemicals known as parabens and phthalates, which recent studies indicate may be linked to cancer development.

Parabens are chemical preservatives that have been identified as estrogenic and disruptive of normal hormone function. (Estrogenic chemicals mimic the function of the naturally occurring hormone estrogen, and exposure to external estrogens has been shown to increase the risk of breast cancer.)

Phthalates are known to cause a broad range of birth defects and lifelong reproductive impairments in laboratory animals that are exposed to these chemicals during pregnancy and after birth. Phthalates are also known to be hormone-mimicking chemicals, many of which disrupt normal hormonal processes, raising concern about their implications for increased breast cancer risk.

There are numerous other chemicals of concern in personal care products. BCA is particularly concerned about lutein (progesterone), formaldehyde and coal tar due to their links to cancer. The Environmental Working Group recently released Skin Deep, a report on the safety of cosmetics and personal care products. Astonishingly, 1/3 of products tested contain on or more ingredients that are known, probable or possible human carcinogens.

Cosmetic companies will argue that we don’t need to worry about harmful chemicals in their products because they are only used on our skin and hair. For example, the cosmetics industry has long stated that their widespread use of parabens and phthalates is not harmful because they remain on our skin and are not absorbed into our body. However, a recent study found parabens in human breast cancer tissue, raising obvious questions about the ability of parabens to accumulate in our bodies (Darbre et al. 2004). In September 2000 scientists from the Centres for Disease Control and Prevention (CDC) found phthalates at surprisingly high levels in every one of 289 people tested, especially in women of reproductive age. The authors concluded that “from a public health perspective, these data provide evidence that phthalate exposure is both higher and more common than previously suspected” (Blount et al. 2000).

Many cosmetic companies will also argue that the level of a harmful chemical in any one product is not enough to harm you, based on studies of chemical exposure in adults. However, science is finding the timing of exposure is crucial, and that even a very small dose of some chemicals can have serious consequences in children and young women who are still developing. Also, we are rarely exposed to a chemical just one time. We may use the same product every day, several days a week, for months or years. In addition, we use dozens of personal care products daily, not just one. So while exposure from one product on one day may be small, the fact is we use numerous products a day for extended periods of time. As a result, scientists are finding chemicals such as parabens and phthalates accumulating in our bodies.

Many diseases like cancer, asthma, birth defects and learning disabilities are on the rise, and there is growing evidence that these health problems are linked to the chemicals we are exposed to in our air, water, food, and everyday products. It’s time we start acting to protect human health. The Precautionary Principle, a common sense approach to chemical use, says “an ounce of prevention is worth a pound of cure”. It guides us to take action to prevent exposure to chemicals we know or suspect is harmful to our health. In the case of cosmetics, when a product ingredient is known or strongly suspected of being harmful to our healthy, our top priority should be eliminating the use of this chemical and finding a safe substitute to replace it. In many cases, we know safe alternatives do exist and are already being used by some cosmetic companies. The notion of “safe” or “acceptable” levels of hazardous chemicals in our products should only be introduced when we cannot find alternatives. We are entitled to products that won’t hurt us.